Mouse Pointer ( Cursor ) Not Responding

My friend is having a problem with his mouse not working. He is able to move the mouse cursor around but then it doesn't respond when clicking on an icon, taskbar, or anything. Can anyone help diagnose the problem we are are having?

He is running windows xp 32bit and his comp is really old (his mouse still uses the track ball and is not via usb port) and i think his pc has some other problems of it's own that could be related to this, but i don't know.

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